To turn off Real-time Protection, double click at Windows Defender icon in the taskbar, click Virus & threat protection and then at Virus & threat Protection settings set to OFF the Real-time Protection and the Cloud-delivered protection. Turn OFF Windows Defender Antivirus Real Time Protection. Disable Windows Defender Antivirus from Windows GUI. Disable Windows Defender Antivirus by editing the registry Offline. How to Disable Windows Defender Security Center (Antivirus, Firewall, etc.) Method 1. So, follow the steps in this tutorial only if you face problems with Windows Defender protection or if you want to permanently remove the Windows Defender antivirus and/or firewall for other reasons. That means that if you install another security program to protect your PC, Windows Defender will be disabled automatically by Windows 10 and there is no need to perform any other action to disable Defender. Before you continue to apply the steps mentioned below, you must know that Windows 10, enables by default the Defender Antivirus and the Defender Firewall, if no any other security program has installed on the computer. This tutorial shows the way to completely disable Defender Security Center and all the Defender protection services (Antivirus, Firewall, Threat protection) in Windows 10.